Peter Attia – An Advantaged Metabolic State: Human Performance, Resilience & Health

A man after my own heart! 

Favorite quote: “... I actually really like the feeling of ketones powering my brain…. There’s really a unique feeling (that’s unlike anything I can describe) which is at 4 PM having this mental focus that I once only had for two hours of the day…  It may be that the sugar restriction alone gets you much of that… it probably does… but two years in I’ve just noticed enough changes that justify the trade-offs (of which there are many).”

Peter Attia is a relentless self-experimenter, obsessed with the idea of a “quantified self.” In the presentation he will share two components of his physical transformation as he evolved from “fit but fat and metabolically deranged” to “fit, lean, and metabolically dialed in.” In particular, Peter will focus on the possible advantages of a ketogenic diet, and in the process share much of what he’s learned implementing it in himself and hundreds of others over the past two years.

Peter is the President and co-founder of the Nutrition Science Initiative (NuSI), a California-based 501(c)(3). Peter is also a physician and former McKinsey & Company consultant, where he was a member of both the corporate risk and healthcare practices. Prior to his time at McKinsey, Peter spent five years at the Johns Hopkins Hospital as a general surgery resident, where he was the recipient of several prestigious awards and the author of a comprehensive review of general surgery. Peter also spent two years at the National Institutes of Health as a surgical oncology fellow at the National Cancer Institute under Dr. Steve Rosenberg, where his research focused on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer.

Peter is a 2012/2013 recipient of the French-American Foundation Young Leader’s Fellowship, which recognizes the most promising leaders under 40. Peter earned his M.D. from Stanford University and holds a B.Sc. in mechanical engineering and applied mathematics from Queen’s University in Kingston, Ontario, Canada, where he also taught and helped design the calculus curriculum.

Healing Chronic Injuries

I’ve been thinking a lot about healing “chronic” injuries, the kind where one has injured and then re-injured oneself over and over, perhaps over the course of years.

It seems to me that such an injury would put repeated demands on the body to produce new cells, accelerating the aging of the stem cells that produce the tissue and thus accelerating the aging of the injured area, making the problem worse…  Not what we want!

Imagine how helpful it would be to replace or “upgrade” the tired stem cell(s) making this tissue.   If we could get healthier stem cell(s) “on the job” in this area,  their healthy daughter cells could build strong young tissue to replace the chronically injured tissue.  This is what I think may be happening when I use telomere support products like “Product B” and “Recharge” – the damaged stem cells are often either replaced or improved, and these healthier stem cells can then make the healthier somatic cells that constitute the healed tissue.

Makes sense to me.   I don’t have conclusive proof, but the theory matches my own experience and Walter’s story of Reclaimed Glory.

High Intensity Training

from http://www.ketogenic-diet-resource.com/high-intensity-interval-training.html

The key is in stressing your muscles hard enough and long enough to recruit all of the muscle fibers into action.

There are three types of muscle fibers:

  • Slow twitch, which has stamina, a little strength, and a quick recovery
  • Medium twitch, which has less stamina, more strength, and a slower recovery
  • Fast twitch, which has little stamina, lots of strength, and a very slow recovery.

If you work your muscles at enough of an intensity for at least 90 seconds before they fail, all three types of muscle fibers will be called upon to do the work. Once all of these muscle fibers are called on to work, it causes a chemical cascade in the muscle which dumps the stored sugar/glycogen, which in turn increases not only the muscle’s size and strength, but also its insulin sensitivity and fat burning potential.

At that point, the causes of why we get fat are being reversed, glycogen tanks are less full, muscle cells become very sensitive to insulin, insulin levels drop, and fat is released from the fat cells so it can burned for fuel. Now the process of good health and weight is going in the right direction.

Here’s a great video featuring a talk by Doug McGuff, the physician who wrote Body by Science: A Research Based Program to Get the Results You Want in 12 Minutes a Week, my go-to book on high intensity interval training.

The video is long and starts slow, but he explains the differences between high intensity exercise and low intensity “aerobic” exercise. He also does a good job of explaining why low intensity exercise like walking/jogging is a factor in metabolic dysfunction.

Jerome’s response: This makes great sense to me, both theoretically and as an explanation for the great results I’m getting in my life.  Since adding “High Intensity Interval Training” to my regimen about 8-10 weeks ago, I’m experiencing significantly greater “depth” of strength, energy and well-being!   After feeling “totally wiped out” after these sessions for the first couple of weeks, I now feel an excited anticipation at the beginning of one, knowing I’m going to quickly deeply challenge myself in a way that increases my health and vitality.

Favorite quote: “For me as an emergency physician, doing this kind of business is the coolest thing, because, you know a lot of times I’m stuck at 3 o’clock in the morning, trying to take care of someone that’s there because of their lifestyle and what they did, and they want no part in participating in any improvement – they just want me to save them in the 11th hour.  That gets very old and frustrating.  What I do down at Ultimate Exercise… is the coolest thing: Because you take the best element of society, that wants to pay you good money. to make them work hard and make them suffer so they can improve themselves and improve their health!  That is magic and that is what I applaud…!

Example workouts:
Dr Doug McGuff Workout (Body by Science author)
“Power of 10” workout coached by Adam Zickerman, author

Joys of Purpose

This week I’ve experienced a profound joy in seeing the beauty of the lives and the people who I can help to live healthier, happier and with more vitality.  It brings tears to my eyes to remember the beautiful looks on their beautiful faces and think that what I do can make a positivie difference in their lives!

They’re already making a huge positive difference in the lives of those they touch…  One is what I call a “keystone person” – a man who stands in the center of an arch of people doing good work in our community – helping him realize his vision will help so many others realize their visions!  I’m excited to be able to use what I’ve learned in such a positive way!

The other is a brilliant, heartfelt author who’s work inspires and informs countless others in what I consider to be the “awakening”, “truth facing” subculture that I judge is so necessary to our successful awakening into our potential as conscious beings…  I am so happy to have the opportunity to grow myself into someone who can support her in continuing her life’s work longer than she otherwise could!

Vivid dream patterns

Last night I once again experienced unusually vivid, memorable dreams.  Once again these dream followed my having taken “Recharge” with 12-16 ounces of half-and-half.

This experience corroborates Dr. Park’s hypothesis that Cycloastragenol  is better absorbed when taken with fat.

Telomerase gene insertion via Adeno Activated Virus

At the American Academy for Anti-Aging Medicine conference, Nov 2014,  Bill Andrews presentation included a report that Sierra Sciences is under contract to develop a way to insert the Telomerase gene into dog, cat and human cells using an Adeno Associated Virus:Adeno_associated_virusand that this has been successful in allowing the infected cells to survive well past the Hayflick limit (control cells in purple below, infected cells in green):Adeno_associated_virus_results

Watch the talk here.

Wow!  This is a HUGE, in my opinion.

On Bill Andrews’ 0-100+ scale of Telomerase Activation, the most potent molecule he’s found has been TAM-818 with a score of 16, but with this virus-mediated gene therapy he appears to be saying they’ve found a way to activate Telomerase at the level of 100 and beyond!

My mind reels at the potential implications!

While Telomerase Activators have the quality of “tapping the gas pedal” on Telomerase, this approach seems more like “bolting the gas pedal permanently down”!

I’m glad to hear that the in vitro results look so good – I’m really curious to hear what the in vivo results will be when they begin testing with dogs and cats…

Sponsoring

Yesterday I chose to sponser a most worthy friend’s personal experiment with the supplements and meditations I’ve been using.

I feel really good about this!

It feels like the most powerful form in which I can give, and I feel really blessed to have a friend who has “what it takes” to give me confidence that the total of positive life energy will grow by my helping them grow their energy.

Yay!2015-08-21-pops-setup

Testing TAM-818, the most powerful molecule so far

On July 21, my first supply of Sierra Sciences TAM-818 molecule arrived, in the form of TAM-818-OneTruth_seruman expensive skin serum.

Dr. Bill Andrews reported that TAM-818 is a product of medical chemistry and scored Telomerase Activation potency of 16 on Sierra Sciences scale of 1 to 100.  As best I recall, TA-65 was between 2 and 3, and the early releases of Product B were similarly low, perhaps 3 or 4, while the newer releases of Product B are reputed to be higher (maybe 5 or 6?).

In any case, this new molecule is said to be significantly stronger than anything I’ve previously had access to!

The question became: How best to test / use it?

I’m not really interested in helping my skin look healthier than my body, underneath it.  I actually like having my skin be a “window” into my bodily health.  So I’m choosing not to use the skin “serum” as directed.

But I do have an inguinal hernia I’ve been wanting to heal.   I’ve been considering the possibility that short telomeres (say in conjunction with an exhausted / senescent stem cell) may be a factor in this hernia.   Intrigued by Dr. Park’s theory that TA-65 promotes apoptosis of defective stem cells, and extending this hypothesis to Telomerase Activators in general, I reason that applying TAM-818 locally could be a good experiment.

So that’s what I’ve chosen to do.   Apply a single “pump” of the TAM-818 serum, nightly, to the skin above the iguinal hernia.

Meanwhile, to test the serum’s effect on my skin, I’ve chosen to apply the serum, once per day at night, to one side of my neck, and watch for changes…

Other applications I have in mind include the post-fat-loss “big skin” that remains around my gut – it seems to me that “youthening” the cells in this area might tighten up that skin.   I’m not testing that, now, as this serum is too dear, at $229 for 50ml, and now I see that replacing it today would be $289…

Supercharging

2015-08-21-pops-setupLately I’ve been experimenting with “Supercharging” the process of Activating Telomerase in the cells that need it the most…I

What I do is crack open a couple of Product B soft-gels between my teeth and allow the liquid herbal extract concentrate absorb into the mucus membranes inside my mouth and throat, and then put my body through a very demanding Yoga class while imagining the intense bodily exertion driving the Telomerase Activating Molecules deep into my cells, all the nucleus, and there activating Telomerase in those cells that divide subsequent to the Yoga.

I feel like it really “pumps” the Telomerase Activating Molecules to the places where the growth is taking place!

[I realize that this kind of visualization is arguably silly.  I’m choosing to do it because, in light of the Placebo Effect, I imagine that this kind of visualization can give me improved results, and it’s also fun!]

Placebo Meditation

After reading Dr. Joe Dispenza’s You Are the Placebo, was excited to try the guided meditations that he’s crafted to help engage / take advantage of that effect.

I’ve been practicing these guided meditations since returning from Europe about six weeks ago and I’m *loving* the results!

The immediate result is that each day I have two “Peak Experiences“, lasting several minutes, during which I have the experience of living the life of my dreams!  This itself has been “worth the price of admission” – I’m getting to experience ecstatically happy states more often, more of the time.   Through repeated practice, I’m getting better at getting a happy state.    In addition, the rest of my day / life seems to go much better after getting into such a state of being…

The longer-term result is that I’m changing my life trajectory to align with my dreams, by re-wiring my brain and activating new genes in new ways!

(That’s the idea, anyway)

Placebo Effect

Since beginning this Cellular Age Reversal Experiment 18 months ago, I’ve realized that “Placebo Effect” could be a factor in any results I achieve.

As I saw more results, I grew more and more curious about how I could differentiate between “placebo” and “substance” causes.

I’ve read Dr. Joe Dispenza’s You Are the Placebo and learned that this effect can  be very, very powerful.  I’ve also learned that the way I’ve approached and performed my Experiment provided the right “set up” to engage the Placebo effect.   I conclude that the Placebo effect could have made a major contribution to my results to date.  I tell myself that the Placebo effect does not have enough power to lengthen telomeres or reverse aging, so I think there’s been some combination of telomerase activation, improved apoptosis, and placebo effect at work in my results.

From the beginning I’ve said that I don’t really care whether the Placebo effect is causing some of my positive results, as long as I’m getting positive results.  I still feel that way.

I’m really glad that I didn’t buy into the popular fear that Telomerase Activation might promote cancer, as I now see that such a fear supports a “bad Placebo” effect, (sometimes called a Nocebo).  I don’t want that kind of effect!

Cellular Age Reversal Experiment

This last month, I’ve begun describing what I’m doing as either my:

Cellular Age Reversal Experiment

                                or

DNA Age Reversal Experiment

because I realize that’s what I’m doing – an experiment attempting to reverse aging at the Cellular, or more accurately the DNA / Chromosomal level.

I now realize that my priority has been to succeed at reversing aging, more than to learn exactly what to attribute that reversal to…  I’ve chosen to change more than one variable at a time, so now that I’ve achieved positive results I’m not clear which change to attribute them to.

Update

In the last couple of weeks several different friends and acquaintances have remarked how great I look and how much youthful energy I have!

I’m hearing:

“Whatever you’re doing, it’s working!”

“Your eyes are so clear!”

“Every time I see you, there’s less wrinkles!”

“Your skin looks so healthy!”

2015-08-10-headstand

iPhone focus was failing, but image still shows my younger-looking body condition, at age 62, 18 months into my Cellular Age Reversal Experiment

Stanford: Telomere extension turns back aging clock in cultured human cells, study finds

uEvidence continues to accumulate in support of the theory that Telomerase Activation reverses aging.     Just ran across this news from researchers at Stanford:

Telomere extension turns back aging clock in cultured human cells, study finds

Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells. Cell proliferation capacity was dramatically increased, yielding large numbers of cells for study.

Jan 22 2015

Helen Blau

Helen Blau

A new procedure can quickly and efficiently increase the length of human telomeres, the protective caps on the ends of chromosomes that are linked to aging and disease, according to scientists at the Stanford University School of Medicine.

Treated cells behave as if they are much younger than untreated cells, multiplying with abandon in the laboratory dish rather than stagnating or dying.

The procedure, which involves the use of a modified type of RNA, will improve the ability of researchers to generate large numbers of cells for study or drug development, the scientists say. Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells. The research may point to new ways to treat diseases caused by shortened telomeres.

Telomeres are the protective caps on the ends of the strands of DNA called chromosomes, which house our genomes. In young humans, telomeres are about 8,000-10,000 nucleotides long. They shorten with each cell division, however, and when they reach a critical length the cell stops dividing or dies. This internal “clock” makes it difficult to keep most cells growing in a laboratory for more than a few cell doublings.

‘Turning back the internal clock’

“Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life,” said Helen Blau, PhD, professor of microbiology and immunology at Stanford and director of the university’s Baxter Laboratory for Stem Cell Biology. “This greatly increases the number of cells available for studies such as drug testing or disease modeling.”

A paper describing the research was published today in the FASEB Journal. Blau, who also holds the Donald E. and Delia B. Baxter Professorship, is the senior author. Postdoctoral scholar John Ramunas, PhD, of Stanford shares lead authorship with Eduard Yakubov, PhD, of the Houston Methodist Research Institute.

The researchers used modified messenger RNA to extend the telomeres. RNA carries instructions from genes in the DNA to the cell’s protein-making factories. The RNA used in this experiment contained the coding sequence for TERT, the active component of a naturally occurring enzyme called telomerase. Telomerase is expressed by stem cells, including those that give rise to sperm and egg cells, to ensure that the telomeres of these cells stay in tip-top shape for the next generation. Most other types of cells, however, express very low levels of telomerase.

Transient effect an advantage

The newly developed technique has an important advantage over other potential methods: It’s temporary. The modified RNA is designed to reduce the cell’s immune response to the treatment and allow the TERT-encoding message to stick around a bit longer than an unmodified message would. But it dissipates and is gone within about 48 hours. After that time, the newly lengthened telomeres begin to progressively shorten again with each cell division.

The transient effect is somewhat like tapping the gas pedal in one of a fleet of cars coasting slowly to a stop. The car with the extra surge of energy will go farther than its peers, but it will still come to an eventual halt when its forward momentum is spent. On a biological level, this means the treated cells don’t go on to divide indefinitely, which would make them too dangerous to use as a potential therapy in humans because of the risk of cancer.

This new approach paves the way toward preventing or treating diseases of aging.

The researchers found that as few as three applications of the modified RNA over a period of a few days could significantly increase the length of the telomeres in cultured human muscle and skin cells. A 1,000-nucleotide addition represents a more than 10 percent increase in the length of the telomeres. These cells divided many more times in the culture dish than did untreated cells: about 28 more times for the skin cells, and about three more times for the muscle cells.

“We were surprised and pleased that modified TERT mRNA worked, because TERT is highly regulated and must bind to another component of telomerase,” said Ramunas. “Previous attempts to deliver mRNA-encoding TERT caused an immune response against telomerase, which could be deleterious. In contrast, our technique is nonimmunogenic. Existing transient methods of extending telomeres act slowly, whereas our method acts over just a few days to reverse telomere shortening that occurs over more than a decade of normal aging. This suggests that a treatment using our method could be brief and infrequent.”

Potential uses for therapy

“This new approach paves the way toward preventing or treating diseases of aging,” said Blau. “There are also highly debilitating genetic diseases associated with telomere shortening that could benefit from such a potential treatment.”

Blau and her colleagues became interested in telomeres when previous work in her lab showed that the muscle stem cells of boys with Duchenne muscular dystrophy had telomeres that were much shorter than those of boys without the disease. This finding not only has implications for understanding how the cells function — or don’t function —  in making new muscle, but it also helps explain the limited ability to grow affected cells in the laboratory for study.

The researchers are now testing their new technique in other types of cells.

“This study is a first step toward the development of telomere extension to improve cell therapies and to possibly treat disorders of accelerated aging in humans,” said John Cooke, MD, PhD. Cooke, a co-author of the study, formerly was a professor of cardiovascular medicine at Stanford. He is now chair of cardiovascular sciences at the Houston Methodist Research Institute.

“We’re working to understand more about the differences among cell types, and how we can overcome those differences to allow this approach to be more universally useful,” said Blau, who also is a member of the Stanford Institute for Stem Cell Biology and Regenerative Medicine.

“One day it may be possible to target muscle stem cells in a patient with Duchenne muscular dystrophy, for example, to extend their telomeres. There are also implications for treating conditions of aging, such as diabetes and heart disease. This has really opened the doors to consider all types of potential uses of this therapy.”

Other Stanford co-authors of the paper are postdoctoral scholars Jennifer Brady, PhD, and Moritz Brandt, MD; senior research scientist Stéphane Corbel, PhD; research associate Colin Holbrook; and Juan Santiago, PhD, professor of mechanical engineering.

The work was supported by the National Institutes of Health (grants R01AR063963, U01HL100397 U01HL099997 and AG044815), Germany’s Federal Ministry of Education and Research, Stanford Bio-X and the Baxter Foundation.

Ramunas, Yakubov, Cooke and Blau are inventors on patents for the use of modified RNA for telomere extension.

Progress Report – Nine Months

At almost 9 months into my personal trial of Telomerase Activation, I can report the following:

  • Improved Energy
  • More Optimistic Outlook
  • Smoother, younger looking skin
  • Lots of new dark hairs coming in on my
    • mustache
    • beard
    • eyebrows
    • bald spot
  • Pre-cancerous(?) patch of abnormal skin formerly on my nose has disappeared
  • Sleeping much better
  • No longer getting up at night to pee
  • Lower body fat
  • Formerly fast-growing nose hairs have slowed down to the rate they were growing perhaps 20 years ago
  • Improved love life
  • Improved mental acuity – learning new computer programming techniques is much easier

Feeling Great!!!

I’m feeling GREAT!

Positive!

Pumped up!

I’m becoming the man I’ve wanted to be!

I’m just back from the gym.  I’m on about day 17 of my Isagenix 30 day cleansing and fat burning program.  Today is a “cleanse” day.  I started at the gym the same day I started the Isagenix 30 day program, because I wanted to remind my body to burn only fat and no muscle, and because I felt I would transform faster if I added exercise to this nutritional program.

I’m listening to Dave MacArthur’s “Mechanic to Millionare” podcast series this morning, becoming more and more clear that I am becoming the open, positive man that I want to be.

 

First Impressions: new softgel “IsaGenesis” Product B

My first shipment of the new “IsaGenesis” formulation of Product B just arrived.

I’m taste-testing it now, having popped a softgel in my mouth a few minutes ago.  I’m holding the resulting mess in my mouth, savoring the flavors and attempting to absorb the active ingredients directly into my bloodstream, bypassing my stomach and liver, seeking maximum absorption.

The taste is bitter and unpleasant.  There’s a new bitter flavor that I never tasted in  the 3rd-gen Product B I’ve been taking since February…  Meanwhile, the familiar “peppery” flavors I’ve grown accustomed to in the previous formulation are not very noticeable in this new formulation.

I wish my herb-tasting palate was more refined!  I can tell the two products taste very different, but I’m having trouble describing what the differences are…  But there’s a big change, in my opinion.   This science stuff is hard!  :-)   From the taste, and the very dark brown color of the new softgel, I thought maybe the tumeric color of the old Product B was gone, but getting a glass and spitting out the mess I see that the orange color is still very much there…

I judge that this new formulation will be harder to “take” sublingually.

But then I’ve only ever heard of one other person taking it sublingually.   From the marketing, I gather that much of the alleged improved effectiveness stems from better absorption with the new formulation.

That’s it for now.

Lab Test: my average telomere length in white blood cells

On April 29, 2014 I had blood drawn for a “Mean Telomere Length” test done by Spectracell laboratories.

The results, which came back on May 27, were a score of 6.81, which I interpret to mean my average telomere length in my white blood cells measured at 6,810 “base pairs”, which is about average for people my age  [My score was in the 48th percentile, so I scored a bit lower than the average].

That’s my “baseline”, from which the normal pattern would be to have the telomeres continue to shorten.     But if I can induce Telomerase Activation, I’d expect my telomeres to lengthen, and this would show as an increase of my test score.

So I plan to repeat the test around Sept 29 and see what has changed six months from now.